SOD1 — Magnaporthe oryzae 70-15

Summary

MGG_02625 (MoSOD1) on chromosome 7 of Magnaporthe oryzae 70-15 encodes a copper-zinc superoxide dismutase, an enzyme with superoxide dismutase activity and oxidoreductase activity acting on sulphur-group donors with oxygen as acceptor, binding copper. The gene is associated with removal of superoxide radicals, cell redox homeostasis, cellular copper and zinc ion homeostasis, copper ion transport, protein acetylation and stabilization, appressorium formation, fungal-type cell wall organization, and positive regulation of transcription by RNA polymerase II. The product localizes to the cytoplasm, cytosol, nucleus, and mitochondrial envelope lumen. Phenotypic associations include absent oxidative stress resistance, decreased spore germination, increased necrotic cell death, abnormal vacuolar distribution and nuclear export, and altered cell cycle progression. Studies of related genes in other species link the family to oxidative stress response and reduced virulence.