BD — Magnaporthe oryzae 70-15

Summary

MoBD (MGG_02727) on chromosome 7 of Magnaporthe oryzae 70-15 encodes a small GTPase of the Ras-type family, possessing GTPase activity, GTP binding, and G protein activity (EC 3.6.5.2). The gene is associated with Ras protein signal transduction, the MAPK cascade, small GTPase-mediated signal transduction, and regulation of conidium formation, appressorium formation, spore germination, programmed cell death, melanin anabolism, and deubiquitination. It is linked to maintenance of protein location in the cell, establishment or maintenance of cell polarity, axial and bipolar bud site selection, cytogamy, and protein farnesylation. The product localizes to the plasma membrane, incipient cellular bud site, cellular bud neck, vacuolar membrane, and cell division site. Phenotypic associations include bipolar budding pattern, redox state, mating type switching, entry into G0, osmotic and oxidative stress resistance, and budding rate. Studies of related genes in other species link the family to reduced virulence and oxidative stress response.