OGM1 — Magnaporthe oryzae 70-15

Summary

MGG_02954 (OGM1, also known as MoOGM1, MoPMT5, or PMT1) on chromosome 7 of Magnaporthe oryzae 70-15 encodes a protein O-mannosyltransferase (EC 2.4.1.109) with a PMT_4TMC domain and MIR motifs, localizing to the ER membrane, nuclear membrane, and endomembrane system. The gene is associated with protein O-linked mannosylation, appressorium formation, spore germination, hyphal growth, filamentous growth, cell-substrate adhesion, interaction with host, and fungal-type cell wall organization. It is linked to responses to starvation, neutral pH, and xenobiotic stimuli, as well as regulation of ER unfolded protein response and downregulation of proteolysis. The gene is connected to blast disease in rice and barley. Studies of related genes in other species link the family to loss of pathogenicity, reduced virulence, and altered chitin deposition.