VPS41 — Magnaporthe oryzae 70-15

Summary

MGG_03313 (MoVPS41) on chromosome 4 of Magnaporthe oryzae 70-15 encodes a protein membrane adaptor belonging to the Vps41/Vps8 family, containing clathrin heavy-chain/VPS repeat, TPR-like helical, and WD40 repeat domains. It is a component of the HOPS complex and localises to the late endosome and vacuolar membrane. The gene is associated with endosome vesicle fusion, TGN-to-endosome transport, homotypic vacuole fusion, vacuolar protein sorting, macroautophagy, cellular response to starvation, appressorium formation, asexual reproduction, and morphogenesis. Associations with delayed endocytosis, absent sporulation efficiency, abnormal vacuolar morphology, decreased oxidative phosphorylation, increased hydrostatic pressure resistance, and altered nutrient uptake and stationary-phase entry have been noted. Related genes in other species link the family to vacuolar assembly and calcium sensitivity.