PEP — Magnaporthe oryzae 70-15

Summary

MoPEP (MGG_03600) on chromosome 4 of Magnaporthe oryzae 70-15 encodes a metalloendopeptidase of the M16 family (EC 3.4.24.64) with signal peptidase, endopeptidase activator, quinol-cytochrome-c reductase, and metalloendopeptidase activities. The protein localises to the mitochondrial inner membrane and lumen, where it is part of the mitochondrial processing peptidase complex and complex III. MoPEP is associated with mitochondrial electron transport, ubiquinol to cytochrome c, aerobic respiration, proteolysis, and mitochondrial protein processing. It is linked to phenylpropanoid metabolism, jasmonic acid anabolism, and lipid metabolism. Phenotypic associations include delayed respiratory growth, decreased oxidative phosphorylation, absent desiccation resistance, increased mitochondrial genome maintenance, premature cell cycle passage through the metaphase-anaphase transition, abnormal meiosis, decreased apoptosis, and absent mating response. The gene is also linked to increased utilization of nitrogen source, decreased fermentative growth, and abnormal peroxisomal morphology.