AD-4 — Magnaporthe oryzae 70-15

Summary

MoAD-4 (MGG_03645) on chromosome 4 of Magnaporthe oryzae 70-15 encodes an adenylosuccinate lyase, a carbon-nitrogen lyase (EC 4.3.2.2) that catalyzes two steps in the de novo AMP biosynthetic process. The gene is associated with purine nucleotide anabolism, hyphal growth, and autophagy. The protein localizes to both the cytosol and nucleus. Phenotypic associations link MoAD-4 to abnormal colony color, decreased sporulation efficiency, altered cell cycle progression (G1 and G2 phases), increased invasive growth, auxotrophy, and changes in nutrient utilization, stress resistance (UV, alkaline pH, freeze-thaw), and lifespan. Studies of related genes in other species connect the adenylosuccinate lyase family to vegetative growth and starvation resistance.