GAP1 — Magnaporthe oryzae 70-15

Summary

MGG_03846 (MoGAP1) on chromosome 6 of Magnaporthe oryzae 70-15 encodes a GTPase-activating protein with a RasGAP domain and Rho GTPase activation protein family features. The product exhibits GAP activity, calmodulin binding, F-actin binding, and cytoskeletal adaptor activity. MoGAP1 is associated with mitotic actomyosin contractile ring assembly, actin filament organization, contractile ring contraction, and actomyosin ring assembly, as well as TOR signaling, autophagy, sporulation, signal transduction, and cell growth. It localizes to the actomyosin contractile ring, neck ring, division septum, mating projection, spindle pole body, and cell cortex. Related genes in other species are linked to increased virulence, loss of pathogenicity, and reduced virulence.