SEC22 — Magnaporthe oryzae 70-15

Summary

MoSEC22 (SEC22) on chromosome 6 of Magnaporthe oryzae 70-15 encodes a SNARE protein containing a Longin domain and a v-SNARE coiled-coil domain. The gene is associated with vesicle fusion at the Golgi apparatus, ER-to-Golgi transport, and cis-Golgi to rough ER transport. It is linked to appressorium formation, host invasion, actin cytoskeleton organization, secretion, endocytosis, and membrane fusion. The protein localizes to COPII-coated vesicle membranes, ER exit sites, SNARE complexes, Golgi membranes, and ER membranes. Associations with turgor pressure, abnormal Golgi and ER distribution, absent vacuolar transport, decreased cell fusion, and absent spore germination have been noted. Studies of related SEC22 family members in other species link the family to reduced virulence.