ARG7 — Magnaporthe oryzae 70-15

Summary

MoARG7 (MGG_04210) on chromosome 6 of Magnaporthe oryzae 70-15 encodes a protein with acetylornithine glutamate acetyltransferase activity (EC 2.3.1.35) and acetyl-CoA:L-glutamate N-acetyltransferase activity (EC 2.3.1.1), placing it in the ArgJ family of arginine biosynthesis proteins. The gene is associated with ornithine and arginine anabolism, the urea cycle, protein synthesis, pigmentation, hyphal growth, and sexual reproduction. Its product localises to the mitochondrial lumen. MoARG7 is linked to abnormal mitochondrial transport and genome maintenance, decreased pexophagy, reticulophagy and mitophagy, altered respiratory growth and nitrogen utilisation, increased stress, metal and chemical resistance, increased replicative and chronological lifespan, and variable competitive fitness. The gene is also associated with blast disease in rice and barley. Related genes in other species link the family to oxidative stress response and sporulation.