FIM — Magnaporthe oryzae 70-15

Summary

MoFIM (MGG_04478) encodes a fimbrin/plastin family protein with F-actin binding, protein binding (bridging), calcium ion binding and metal binding activities. This gene on chromosome 1 of Magnaporthe oryzae 70-15 is associated with actin cytoskeleton organization, including formin-nucleated actin cable organization, actin filament bundle assembly, actin cortical patch organization, actomyosin contractile ring organization, and hyphal growth. It is also linked to endocytosis and vesicle transport. The protein localizes to actin bodies, actin filament bundles, F-actin, actin patches, the actomyosin contractile ring, the medial ring, the cell division site, and the cytoplasm. Associations with abnormal filamentous growth, cell cycle progression, endocytosis, budding, cell fusion, and increased polyploidy have been observed. Related genes in other species link the fimbrin family to reduced virulence.