HMT1 — Magnaporthe oryzae 70-15

Summary

MGG_04584 (MoHMT1) on chromosome 2 of Magnaporthe oryzae 70-15 encodes a protein arginine methyltransferase (PRMT) with arginine omega-N asymmetric methylase, monomethylase and histone methylase activities, and contains an Arg_MeTrfase domain. The gene is associated with regulation of transcription, mRNA export, ribosome biogenesis, autophagy, chromatin modelling and folate biosynthesis, and its product localises to the cytoplasm, cytosol and nucleus. MoHMT1 is linked to increased virulence, altered sporulation and spore germination, abnormal mating and meiosis, premature cell cycle progression, decreased lifespan, and changes in polyploidy, aneuploidy and transposable element activity. Studies of related PRMT family members in other species connect the family to oxidative stress response.