CLM2 — Magnaporthe oryzae 70-15

Summary

MoCLM2 (MGG_04684) on chromosome 1 of Magnaporthe oryzae 70-15 encodes a cytochrome P450 family protein with phenylacetate hydroxylase and 3-hydroxyphenylacetate 6-hydroxylase activity, acting as an oxidoreductase that incorporates molecular oxygen. The gene is associated with demethylation, penicillin anabolism, mitophagy, sporulation, and hyphal growth. It has been linked to numerous phenotypes including decreased micronucleophagy and ribophagy, increased cell death, arrested vegetative and exponential growth, abnormal cell cycle progression, decreased invasive growth, increased fermentative metabolism, and altered nutrient utilization. The encoded protein localizes to membranes. Studies of related cytochrome P450 genes in other fungi link the family to sterol 14α-demethylase activity and protein content traits, though these associations are not yet established in M. oryzae.