CPD1 — Magnaporthe oryzae 70-15

Summary

MoCPD1 (MGG_04871) on chromosome 3 of Magnaporthe oryzae 70-15 encodes a tRNA(m1A58)-methyltransferase subunit TRM61, a SAM-dependent methyltransferase that catalyses the 2.1.1.220 reaction. The gene is annotated to tRNA methylation, methylation, and ergosterol anabolism. The encoded protein localises to the cytosol, nucleus, and the tRNA(m1A) methyltransferase complex. MoCPD1 is associated with numerous phenotypes, including increased resistance to osmotic stress, oxidative stress, and alkaline pH, as well as increased anaerobic growth, chronological lifespan, and replicative lifespan. It is also linked to decreased biofilm formation, endocytosis, and UV resistance, along with abnormal cell cycle progression, delayed G1/S phase transition, and decreased nucleolus size. Related genes in other species connect the family to tRNA methylation.