SKP1 — Magnaporthe oryzae 70-15

Summary

MGG_04978 (MoSKP1, also known as SCON-3) on chromosome 3 of Magnaporthe oryzae 70-15 encodes an E3 ubiquitin ligase complex SCF subunit, a member of the SKP1-like protein family, with cullin family protein binding and ligase activity. The gene is associated with protein ubiquitination, ubiquitin-dependent proteolysis, the ERAD pathway, and the proteasomal pathway, as well as with spore germination, tube development, circadian rhythm, innate immunity, and the ER stress response. It has been linked to blast disease in rice (Oryza sativa). Associations also include regulation of DNA recombination, sumoylation, desumoylation, mitotic cell cycle progression, and meiotic recombination. The product localises to the cytoplasm, nucleus, ssDNA-dependent ATP-dependent DNA helicase complex, and RAVE complex. Related genes in other species link the family to SCF-dependent proteasomal ubiquitin-dependent protein breakdown and nuclear SCF complex localisation.