GB-1 — Magnaporthe oryzae 70-15

Summary

MGG_05201 (GB-1) on chromosome 3 of Magnaporthe oryzae 70-15 encodes a guanine nucleotide-binding protein subunit beta, a WD40-repeat-containing G-protein beta subunit. The encoded protein is associated with signaling receptor complex adaptor activity, GTP binding, and transcription corepressor activity, and localizes to heterotrimeric G-protein complexes, transcription repressor complexes, and chromatin. GB-1 is associated with GPCR signaling, the glucose-sensing PKA pathway, the HOG response, quorum sensing, and negative regulation of isoprenoid metabolism and fatty acid anabolism. It is associated with host invasion, development of symbiont in host, mitigation of host defenses, and phenotypic switching. Related genes in other species are linked to loss of pathogenicity and reduced virulence.