FZO1 — Magnaporthe oryzae 70-15

Summary

MGG_05209 (MoFZO1) on chromosome 3 of Magnaporthe oryzae 70-15 encodes a mitofusin-family transmembrane GTPase with dynamin and P-loop NTPase domains, possessing GTPase motor activity, GTP binding and GTPase activity. The gene is associated with mitochondrial outer membrane fusion, mitochondrial fusion and fission, mitophagy, mitochondrial localisation, and invasive growth. It is linked to rice blast disease. Annotated phenotypes include decreased colony sectoring, absent peroxisomal transport and morphology, abnormal endoplasmic reticulum, Golgi and vesicle distribution, delayed vegetative growth, cell cycle progression and autophagy, increased polyploidy, decreased radiation resistance, altered fermentative and respiratory metabolism, and numerous other cellular and developmental abnormalities. Studies of related genes in other species link the family to sporogenesis and oxidative stress response.