BIM1 — Magnaporthe oryzae 70-15

Summary

MGG_05427, designated MoBIM1 (also known as MoMAL3 or MAL3) in Magnaporthe oryzae 70-15 on chromosome 1, encodes a protein containing CH and EB1_C domains. The product exhibits cytoskeletal adaptor activity, microtubule plus-end and lateral binding, ATPase activator activity, and phase separation nucleator activity. MoBIM1 is associated with protein localization to microtubule, regulation of microtubule polymerization or depolymerization, spindle assembly, nuclear division, cell division, cell growth, and establishment or maintenance of cell polarity. It is linked to appressorium-mediated host invasion and nuclear congression. The protein localizes to microtubule plus-ends, astral microtubules, the spindle midzone, and the microtubule-organizing center. Associations with cell cycle progression, including premature metaphase-anaphase transition and delayed G1/S phase transition, have been observed, along with links to increased hydrostatic pressure resistance, altered mating efficiency, and abnormal pseudohyphal growth.