CP1 — Magnaporthe oryzae 70-15

Summary

MGG_05663 (CP1, CPYA) in Magnaporthe oryzae 70-15 on chromosome 1 encodes a serine carboxypeptidase (EC 3.4.16.5) belonging to the peptidase S10 and AB hydrolase families, with a propeptide carboxypeptidase Y domain. The gene is associated with proteolysis, chromatin silencing, and fHC assembly, and its product localises to the fungal-type vacuole lumen. It is linked to numerous cellular processes including autophagy, mitophagy, pexophagy, ribophagy, endocytosis, cytokinesis, nuclear fusion during mating, protein secretion, and Golgi morphology. Phenotypic associations include altered cell death (both increased and decreased), increased aneuploidy, abnormal nuclear position, increased acquired thermotolerance, and increased lifespan. The gene is also connected to prion inheritance, chemical compound accumulation, and replicative lifespan.