CLR6 — Magnaporthe oryzae 70-15

Summary

MoCLR6 (MGG_05857) encodes a histone deacetylase (EC 3.5.1.98) with NAD-independent activity, capable of deacetylating histones H3 and H4 at multiple lysine residues. The protein belongs to the His_deacetylse family and localises to several chromatin-modifying complexes including HDA1, Rpd3S, SHREC, and SET3C. In Magnaporthe oryzae, MoCLR6 is associated with appressorium formation, maturation, and host invasion, as well as ascus development, sexual reproduction, and epigenetic regulation of gene expression. The gene is linked to heterochromatin island assembly, centromeric silencing, and rDNA heterochromatin assembly. MoCLR6 has been connected to blast disease in rice (Oryza sativa). Studies of related genes in other species link the family to cell cycle progression, mating type switching, flocculation, sporulation, and biofilm formation.