SEC4 — Magnaporthe oryzae 70-15

Summary

MoSEC4 (MGG_06135) on chromosome 3 of Magnaporthe oryzae 70-15 encodes a small GTPase with GTP binding and GTPase activity, classified as a Rab-family GTP-binding protein Ypt2. The gene is associated with regulation of vesicle-mediated transport, intracellular protein transport, and protein localization to the meiotic spindle pole body, cell cortex, and growing cell tip. It is linked to host invasion, asexual reproduction, mitotic cytokinesis, vacuole organization, and membrane addition at sites of cytokinesis. Localization evidence connects the product to the transport vesicle membrane, recycling endosome, Spitzenkörper, and cleavage furrow leading edge. Phenotypic associations include abnormal filamentous growth, delayed sporulation, decreased cytokinesis rate, increased pexophagy, and altered cell cycle progression. Related genes in other species link the family to loss of pathogenicity and reduced virulence.