DNM1 — Magnaporthe oryzae 70-15

Summary

MGG_06361 (MoDNM1) on chromosome 4 of Magnaporthe oryzae 70-15 encodes a dynamin GTPase, a member of the dynamin family characterised by GTPase, stalk and GED domains. The encoded protein possesses membrane fusion GTPase activity, membrane scission GTPase motor activity, membrane bending activity, microtubule binding, lipid binding, GTP binding, identical protein binding and metal binding. MoDNM1 is associated with mitochondrial inner membrane fusion and fission, peroxisome fission, vesicle scission, cytokinesis, heme transport, receptor internalization, pexophagy, homotypic vacuole fusion, host invasion, and microtubule-mediated mitochondrion localization. It localises to the mitochondrial outer and inner membranes, peroxisome, fungal-type vacuole membrane, Golgi complex, cell division site, plasmalemma and microtubules. The gene is linked to blast disease in rice, and associations include decreased vegetative growth, increased necrotic cell death, abnormal filamentous growth, decreased adhesion, and altered cell cycle progression, chromosome segregation, endocytosis, autophagy and respiratory metabolism.