RGA5 — Magnaporthe oryzae 70-15

Summary

MGG_06390 (MoRGA5, also known as MoSAC7) on chromosome 4 of Magnaporthe oryzae 70-15 encodes a Rho GTPase-activating protein (RhoGAP) with small GTPase binding, GAP activity, lipid binding, and metal binding functions. The gene is associated with downregulation of Rho protein signal transduction, regulation of actin cable assembly, positive regulation of establishment of cell polarity regulating cell shape, positive regulation of establishment of bipolar cell polarity, regulation of cell wall organization or biogenesis, negative regulation of cell integrity MAPK cascade, and immune response. It is also linked to cell death, signal transduction, and regulation of fungal-type cell wall 1,3-alpha-glucan and (1->3)-beta-D-glucan biosynthetic processes. The protein localizes to the cell cortex, growing cell tip, site of polarized growth, and actomyosin contractile ring. Associations with barley and rice blast disease, as well as numerous phenotypes including abnormal spore germination, budding, cell cycle progression, pheromone sensitivity, and thermotolerance, have been observed.