ACH1 — Magnaporthe oryzae 70-15

Summary

MoACH1 (MGG_06609) on chromosome 4 of Magnaporthe oryzae 70-15 encodes a protein with acetyl-CoA hydrolase and acetate CoA-transferase activities, belonging to the acetyl-CoA hydrolase family. The gene is associated with acetate metabolism, catabolism, and cellular response to basic pH. It has been linked to autophagy, including macroautophagy, ER-phagy, and mitophagy, as well as appressorium formation, immune response, and lipid homeostasis. Localisation evidence links the product to mitochondria and cytosol. Phenotypic associations include altered cell cycle progression, increased carbon source utilization, decreased apoptosis, and absent adhesion and protein secretion. Studies of related genes in other species link the family to abnormal carbon source utilization and decreased acid pH resistance.