ILV1 — Magnaporthe oryzae 70-15

Summary

MoILV1 (MGG_06868) on chromosome 1 of Magnaporthe oryzae 70-15 encodes an acetolactate synthase, a thiamine pyrophosphate-dependent enzyme with acetolactate synthase, pyruvate decarboxylase and 2-hydroxyacyl-CoA lyase activities. The gene is associated with branched-chain amino acid biosynthesis, specifically valine, isoleucine and leucine anabolism, as well as fatty acid alpha-oxidation. It is linked to appressorium formation, morphogenesis, homologous recombination and non-homologous end joining. The product localises to the acetolactate synthase complex, peroxisome, mitochondria, cytosol and nucleus. Associations with rice blast disease and barley are recorded. Phenotypic links include altered cell cycle progression, increased vegetative growth and autophagy, increased or decreased osmotic stress resistance, abnormal colony appearance and filamentous growth, and effects on sporulation efficiency, viability and pseudohyphal growth.