CCA1 — Magnaporthe oryzae 70-15

Summary

MGG_07089 (MoCCA1) in Magnaporthe oryzae 70-15 on chromosome 2 encodes a CCA tRNA nucleotidyltransferase, an enzyme that adds the essential CCA terminus to the 3' end of tRNAs. It possesses ATP:3'-CC-tRNA adenylyltransferase and CC tRNA cytidylyltransferase activities, binds CTP, ATP, and RNA, and localises to the mitochondria, nucleus, and cytosol. The gene is associated with tRNA 3'-terminal CCA addition, systemic acquired resistance, penetration peg formation, autophagy, cell development, and differentiation. Phenotypic associations link MoCCA1 to decreased filamentous growth, sporulation, invasive growth, and biofilm formation, as well as altered carbon and nitrogen source utilisation, increased heat sensitivity, and reduced stress resistance. Related genes in other species are linked to abnormal nucleolar morphology and decreased exponential-phase growth.