ELO1 — Magnaporthe oryzae 70-15

Summary

MGG_07280 (ELO1, MoELO1) in Magnaporthe oryzae 70-15 encodes a member of the ELO family of fatty acid elongases, with enzyme activity classified as 2.3.1.199 and ELOVL function. The gene is associated with very-long-chain fatty acid anabolism, including elongation of saturated, monounsaturated, and polyunsaturated fatty acids, as well as sphingolipid anabolism. It is linked to host invasion and penetration peg formation, and to nuclear membrane organization. The encoded protein localizes to the endoplasmic reticulum, nuclear membrane, cytosol, and nucleus. Phenotypic associations include effects on cell cycle progression, spore germination, filamentous and pseudohyphal growth, cell fusion, and anaerobic and fermentative growth, as well as abnormal prion inheritance and nucleophagy. Studies of related genes in other species link the family to calcium sensitivity, acid sensitivity, oxidative stress response, and protein content.