CTS1 — Magnaporthe oryzae 70-15

Summary

MoCTS1 (MGG_07545) on chromosome 3 of Magnaporthe oryzae 70-15 encodes a CTP synthase, an enzyme with CTP synthase activity (EC 6.3.4.2). The protein contains CTP_synthase_N and GATase1_CTP_Synthase domains, binds ATP and identical proteins, and localises to the cytoplasm, cytosol and cytoophidium. MoCTS1 is associated with pyrimidine base anabolism, homeostasis, and numerous cell cycle and meiotic processes, including arrested meiosis, abnormal G2/M phase transition, delayed metaphase-anaphase transition, and altered S-phase progression. The gene is also linked to increased UV and acid pH resistance, increased starvation resistance, absent mating response and pexophagy, decreased phosphorus utilisation, and abnormal colony shape. Studies of related genes in other species connect the CTP synthase family to oxidative stress response.