MCB — Magnaporthe oryzae 70-15

Summary

MGG_07335 (MCB, also known as SUM1) in Magnaporthe oryzae 70-15 encodes a protein containing a cAMP-dependent protein kinase regulatory subunit domain, a cNMP-binding domain, and a RmlC-like jellyroll domain. The encoded protein exhibits cAMP binding, PKA catalytic subunit binding, cAMP-dependent protein kinase inhibitor activity, and identical protein binding. MCB is associated with appressorium formation and maturation, asexual sporulation, cellular responses to nitrogen and glucose starvation, oxidative stress, and glycogenolysis and lipolysis. It is linked to regulation of cytoplasmic mRNA processing body assembly, downregulation of nuclear division and Ras protein signal transduction, and upregulation of protein export from the nucleus. The gene is associated with rice blast disease. Phenotypic associations include increased virulence, decreased spore germination rate, altered cell cycle progression, and abnormal chromosome segregation. The protein localizes to the cAMP-dependent protein kinase complex, plasma membrane, cytosol, nucleus, and chromatin.