GPX1 — Magnaporthe oryzae 70-15

Summary

MGG_07460 (MoGPX1, also known as MoHYR1) encodes a phospholipid-hydroperoxide glutathione peroxidase with thioredoxin-dependent peroxiredoxin activity (EC 1.11.1.24), belonging to the thioredoxin-like superfamily. In Magnaporthe oryzae, MoGPX1 is associated with cellular detoxification of hydrogen peroxide, cell redox homeostasis, and response to oxidative stress. It is linked to protein desuccinylation, peptidyl-cysteine oxidation, fatty acid and lipid oxidation, the TCA cycle, oxidative phosphorylation, and secretion. The gene product localizes to mitochondria, cytoplasm, cytosol, and nucleus. MoGPX1 is associated with invasive growth and has been connected to blast disease in rice and barley. Associations with turgor pressure, nutrient uptake, osmotic stress resistance, mitochondrial genome maintenance, cell cycle progression, endocytosis, Golgi morphology, fermentative and respiratory metabolism, protein secretion, redox state, acid pH resistance, lifespan, vegetative growth, and mitotic recombination have been reported.