APG7 — Magnaporthe oryzae 70-15

Summary

MGG_07297, also known as APG7 or ATG7 in Magnaporthe oryzae 70-15 on chromosome 2, encodes a protein with Atg7_N and ThiF/MoeB/HesA domains and Atg12 activating enzyme activity. This gene is associated with macroautophagy, mitophagy, and protein modification by small protein conjugation. It has been connected to appressorium formation and maturation, host invasion, asexual sporulation, and programmed cell death. The encoded protein localizes to the cytoplasm and the phagophore assembly site. APG7 is linked to cellular responses to nitrogen starvation, glycogen metabolism, and lipid homeostasis. Related genes in other species are associated with reduced virulence.