CUL1 — Magnaporthe oryzae 70-15

Summary

MGG_07145 (MoCUL1) on chromosome 2 of Magnaporthe oryzae encodes Cullin-1, a scaffold protein of ubiquitin ligase complexes. The gene is associated with protein ubiquitination, the proteasomal pathway, and SCF-dependent proteasomal ubiquitin-dependent protein breakdown. It has been linked to cell division, DNA damage response, circadian rhythm, innate immunity, and transcription. MoCUL1 is associated with heterochromatin silencing at centromeric, telomeric, and mating-type regions, as well as RNAi-mediated heterochromatin assembly. Localisation evidence places the product in the nucleus, cytoplasm, and several E3 ubiquitin ligase complexes including Cul4-RING and CLRC. Phenotypic associations include abnormal cell cycle progression, flocculation, biofilm formation, mating efficiency, meiosis, sporulation, and pheromone response. Related genes in other species link the cullin family to oxidative stress response and SCF complex localisation.