BD — Magnaporthe oryzae 70-15

Summary

MoBD (MGG_06914) encodes a GTP-binding protein of the Ras-type small GTPase family, annotated with GTPase activity, GTP and GDP binding, and protein serine/threonine kinase activator activity. In Magnaporthe oryzae, MoBD is associated with negative regulation of asexual sporulation, cell-substrate adhesion, biofilm formation, and mitigation of host defenses. It is linked to the cAMP/PKA signaling cassette, TORC1 signaling, Ras protein signal transduction, and responses to glucose and nitrogen starvation. The protein localizes to the plasma membrane, endomembrane system, cytosol, and nucleus. Phenotypic associations include decreased vacuolar transport, absent bipolar budding, increased mating-type switching, decreased osmotic and oxidative stress resistance, and altered cell cycle progression. Studies of related genes in other species link the family to reduced virulence.