MSP1 — Magnaporthe oryzae 70-15

Summary

MGG_07075 (MSP1, MoMSP1) on chromosome 2 of Magnaporthe oryzae 70-15 encodes an AAA+ ATPase family protein with ATP-dependent histone chaperone, microtubule-severing ATPase, and membrane protein dislocase activities. It is associated with autophagic cell death, programmed cell death induction, microtubule severing and bundling, membrane fission, MVB formation, extraction of mislocalized protein from mitochondrial outer membrane, and negative regulation of mitochondrial fission. The gene is associated with photosynthesis, jasmonic acid anabolism, and protein hexamerization. Localization evidence connects the product to the ESCRT-IV complex, endosome and peroxisome membranes, mitochondrial outer membrane, and the p97-Ufd1-Npl4 complex. Related genes in other species are associated with loss of pathogenicity and reduced virulence.