ABC1 — Magnaporthe oryzae 70-15

Summary

MoABC1 (MGG_06939) on chromosome 1 of Magnaporthe oryzae 70-15 encodes an ABC1-domain protein with kinase and transferase activity and ATP binding. It is associated with ubiquinone anabolism, defense response, and detoxification, and localizes to the mitochondrial inner membrane. The gene is linked to diverse phenotypes including increased mitochondrial genome maintenance and rho- mutation frequency, abnormal mitochondrial morphology, increased mitophagy, and changes in vegetative growth, biofilm formation, chitin deposition, sporulation efficiency, and carbon source utilization. It also connects to cell cycle progression, lipid particle morphology, and RNA modification. Studies of related genes in other species link the ABC1/ADCK family to mitochondrial function.