HRP1 — Magnaporthe oryzae 70-15

Summary

MoHRP1 (MGG_06881) on chromosome 1 of Magnaporthe oryzae 70-15 encodes an RRM domain-containing protein with poly(A), poly(U), mRNA 3′-UTR, mRNA and RNA binding activities. The gene is associated with regulation of nuclear-transcribed mRNA poly(A) tail shortening, cotranscriptional 3′ processing of RNA polymerase II mRNA transcripts, mRNA 3′-end processing, regulation of translation, TOR signaling, mRNA transport and processing. The product localises to the mRNA cleavage stimulating factor complex, perinuclear region of cytoplasm, post-mRNA release spliceosomal complex, stress granules, RNP, cytoplasm, cytosol and nucleus. MoHRP1 is linked to abnormal protein activity, increased nutrient uptake, increased gamma ray resistance, delayed vegetative growth, increased carbon source utilisation, abnormal prion inheritance and formation, absent innate thermotolerance, decreased fermentative metabolism, absent adhesion, increased RNA modification, decreased anaerobic growth, delayed cell cycle progression, decreased colony size and increased mitochondrial rho- mutation frequency. Related genes in other species are linked to lethal phenotypes.