LHS1 — Magnaporthe oryzae 70-15

Summary

MGG_06648 (LHS1, MoLHS1) in Magnaporthe oryzae 70-15 encodes a hypoxia up-regulated protein 1 belonging to the Hsp70 family, with adenyl-nucleotide exchange factor activity, peptide binding, protein translocase activity, heat shock protein binding, protein folding chaperone activity, and ATP hydrolase activity. It is associated with the endoplasmic reticulum lumen and chaperone complex, and linked to protein folding and localization in the ER, the ERAD pathway, the unfolded protein response, and SRP-dependent and posttranslational membrane targeting and translocation. The gene is associated with appressorium formation, spore germination, host invasion, and negative regulation of host defenses, as well as fungal-type cell wall beta-glucan anabolism and karyogamy. It is also associated with response to heat and toxic substances, and has been linked to blast disease in rice (Oryza sativa).