VPS5 — Magnaporthe oryzae 70-15

Summary

MGG_06743 (MoVPS5) on chromosome 1 of Magnaporthe oryzae 70-15 encodes a vacuolar protein sorting-associated protein Vps5, a member of the BAR_Vps5, Vps5_C and PX domain families. The product binds phosphatidylinositol-3-phosphate and phosphoinositides, and is associated with the retromer complex and SNX-BAR dimer at the endosome membrane. MoVPS5 is linked to protein transport, endocytic recycling, retrograde transport from endosome to Golgi, autophagy of mitochondria, ER-phagy, mitophagy, and the cytoplasm-to-vacuole targeting pathway. It is also connected to the pre-autophagosomal structure and the formation of the fungal-specific membrane compartment. Studies of related genes in other species link the family to reduced virulence and associations with rice blast disease and fusarium head blight.