HSC82 — Magnaporthe oryzae 70-15

Summary

MGG_06759 (MoHSC82) in Magnaporthe oryzae 70-15 encodes a heat shock protein 90 (Hsp90) family chaperone with ATP-dependent protein folding chaperone and ATP hydrolase activities. The gene is associated with diverse biological processes including appressorium formation, spore germination, sporulation, filamentous growth, defense response, innate immunity, protein stabilization, proteasome assembly, and cellular response to heat and xenobiotic stimuli. It is linked to regulation of apoptotic process, metabolic burst, folate metabolism, and Box C/D snoRNP assembly. The protein localizes to the hyphal cell wall, cross wall, extracellular vesicles, mitochondria, plasmalemma, and perinuclear region. Phenotypic associations include abnormal spore germination, decreased hypoosmotic stress resistance, premature apoptosis, altered cell cycle progression, and increased thermotolerance. Related genes in other species link the family to reduced virulence and oxidative stress response.