CDC48 — Magnaporthe oryzae 70-15

Summary

MGG_06686 (CDC48) on chromosome 1 of Magnaporthe oryzae 70-15 encodes an AAA+ ATPase domain-containing protein with ATP-dependent protein disaggregase activity, protein transporter activity, and polyubiquitin modification-dependent protein binding. It is associated with preribosome binding, ubiquitin ligase binding, RNA binding, and ATP hydrolase activity. The gene is linked to diverse biological processes including activation of the cellular response to hypoxic stress, peroxisome matrix protein import and receptor recycling, nuclear protein quality control via the ubiquitin-proteasome system, the INMAD pathway, protein unfolding, protein dislocation from the ER, ribosome-associated ubiquitin-dependent protein breakdown, cytosolic large ribosomal subunit assembly, mitotic spindle breakdown, SREBP signalling, nuclear movement, cell division, and the cell cycle. It localises to the ATPase complex, Vms1-Cdc48-Npl4 complex, Hrd1p ubiquitin ligase complex, RQC complex, p97-Ufd1-Npl4 complex, mitochondrial outer membrane, peroxisome membrane, nucleolus, and chromatin. Related genes in other species are linked to loss of pathogenicity.