HAL4 — Magnaporthe oryzae 70-15

Summary

MoHAL4 (MGG_06420) on chromosome 4 of Magnaporthe oryzae 70-15 encodes a serine/threonine protein kinase (EC 2.7.11.1) with ATP-binding and protein kinase domains. The gene is associated with phospholipid binding and protein phosphorylation, and has been linked to the regulation of iron-sulfur cluster assembly, glycogenolysis, protein lipoylation, cellular potassium ion homeostasis, septin ring assembly, and negative regulation of filamentous growth. It is also connected to cell cycle transitions (G1/S and G2/M), mitotic exit, biofilm formation, and nitrogen utilization. The encoded protein localizes to the septin ring, bud neck, cell tip, nucleolus, mitochondria, and plasma membrane. Phenotypic associations include altered endocytosis, cell cycle progression, biofilm formation, nitrogen source utilization, mating response, and increased resistance to ionic and osmotic stress. Studies of related genes in other species link the family to potassium uptake and acid sensitivity.