ATG1 — Magnaporthe oryzae 70-15

Summary

MGG_06393 (ATG1, MoAPG-1) on chromosome 4 of Magnaporthe oryzae 70-15 encodes a serine/threonine protein kinase (EC 2.7.11.1) with an Atg1-like domain, ATP binding, and protein serine/threonine kinase activity. The gene is associated with autophagy, including autophagic cell death, mitophagy, ER-phagy, and regulation of autophagy, as well as appressorium formation, conidium germination, positive regulation of conidium formation, and the MAPK cascade. It is linked to cellular responses to nitrogen and potassium ion starvation, phospholipid translocation, and cellular homeostasis. The product localizes to the phagophore, pre-autophagosomal structure (PAS), and vacuole-IM contact sites. Associations with abnormal colony size, delayed autophagy, increased necrotic cell death, and decreased cell cycle progression have been recorded. Related genes in other species are linked to the ULK complex and nitrogen and sugar content.