CRN — Magnaporthe oryzae 70-15

Summary

MoCRN (MGG_06389) on chromosome 4 of Magnaporthe oryzae 70-15 encodes a coronin family protein containing WD40 repeats and a DUF1899 domain. The product binds F-actin, microtubules, the Arp2/3 complex, dynein complex, histones, and U4/U6 snRNA, and mediates protein binding bridging. It is associated with positive and negative regulation of Arp2/3-mediated actin nucleation, actin filament bundle assembly and organization, microtubule-based processes, microtubule organizing center organization, vesicle transport, appressorium formation, mitotic spindle orientation, nuclear movement, and chromatin organization. Localization evidence links the protein to endocytic vesicles, F-actin, microtubule-associated complexes, the spindle pole, and the U4/U6.U5 snRNP complex. Phenotypic associations include abnormal filamentous growth, cytokinesis, endocytosis, chitin deposition, spore wall formation, and increased alkaline pH resistance.