ABP1 — Magnaporthe oryzae 70-15

Summary

MoABP1 (MGG_06358) on chromosome 4 of Magnaporthe oryzae 70-15 encodes an amylase-binding protein AbpA containing ADF-H, gelsolin-like, and SH3 domains. The gene product binds F-actin and localizes to actin bodies, cortical actin cytoskeleton, actin patches, cell tips, and division sites. MoABP1 is associated with regulation of actin polymerization, endocytosis, invasive growth, host invasion, and regulation of growth. Phenotypic associations include abnormal filamentous growth, decreased adhesion, delayed or decreased endocytosis, abnormal septum and spore wall formation, decreased cell fusion, altered pheromone sensitivity, increased alkaline pH resistance, and absent innate thermotolerance. The gene is linked to blast disease in rice and barley. Studies of related genes in other species connect the family to actin cytoskeleton organization and endocytic trafficking.