NTE1 — Magnaporthe oryzae 70-15

Summary

MGG_06143 (NTE1, MoNTE1) on chromosome 3 of Magnaporthe oryzae 70-15 encodes a protein with lysophospholipase activity (EC 3.1.1.5) and a patatin-like phospholipase domain, possessing phosphatidylcholine lysophospholipase A1 activity. The gene is associated with phosphatidylcholine metabolism and breakdown, glycerolipid metabolism, lipolysis, and regulation of phospholipid anabolism. It is linked to appressorium formation, secretion, and cell death, and localizes to the endoplasmic reticulum membrane. Associations with Hordeum vulgare and Oryza sativa connect NTE1 to rice blast disease. Phenotypic associations include decreased nucleophagy, absent mitophagy and pexophagy, increased desiccation resistance, decreased invasive growth, abnormal cell wall and endomembrane morphology, and delayed G1 cell cycle progression. Studies of related genes in other species link the family to phospholipid metabolism and autophagy regulation.