FIS1 — Magnaporthe oryzae 70-15

Summary

MGG_06075 (MoFIS1) on chromosome 3 of Magnaporthe oryzae 70-15 encodes a mitochondrial fission 1 protein, a member of the Fis1 family with TPR-like helical domains, and is annotated with bridging and lipid-binding molecular functions. The gene is associated with mitochondrial fission, peroxisome fission, mitophagy, pexophagy, autophagy of the mitochondrion, appressorium formation, host invasion, cytokinesis, and mating. It localises to the mitochondrial outer membrane and peroxisome membrane. Phenotypic associations include absent peroxisomal transport and morphology, absent mitophagy and pexophagy, increased cell death, abnormal colony colour and size, decreased chitin deposition, and altered cell cycle progression. The gene is also linked to blast disease in rice (Oryza sativa). Studies of related genes in other species connect the family to mitochondrial and peroxisomal dynamics.