HIS2 — Magnaporthe oryzae 70-15

Summary

MoHIS2 (MGG_06040) on chromosome 3 of Magnaporthe oryzae 70-15 encodes a histidinol-phosphatase (EC 3.1.3.15), placing it in the histidinol-phosphate phosphatase (HisJ) family with a PHP domain. The gene is associated with histidine anabolism, appressorium formation and maturation, invasive growth, melanin anabolism, carbon catabolite repression, chitin breakdown, lipolysis, response to oxidative stress, and membrane transport. It localises to the cytoplasm and cytosol. Phenotypic associations link MoHIS2 to abnormal mitochondrial transport and genome maintenance, decreased pexophagy, reticulophagy, and mitophagy, increased stress and metal resistance, extended replicative and chronological lifespan, altered competitive fitness, and abnormal nitrogen utilization and chemical compound accumulation. Studies of related genes in other species connect the family to increased lifespan, heat sensitivity, metal resistance, vacuolar morphology, and auxotrophy.