NIAD — Magnaporthe oryzae 70-15

Summary

MoNIAD (MGG_06062) on chromosome 3 of Magnaporthe oryzae 70-15 encodes a protein with nitrate reductase (NADPH) activity (EC 1.7.1.3), sulfite oxidase activity, cytochrome-b5 reductase activity acting on NADH and on NAD(P)H, NADH dehydrogenase activity, transferase activity, and 2-(3-amino-3-carboxypropyl)histidine synthase activity, binding molybdenum cofactor, molybdenum ion, FAD, and heme. The protein belongs to the nitrite/nitrate reductase NADH domain family and contains a cytochrome-b5-like heme/steroid-binding domain. MoNIAD is associated with nitrate assimilation, anaerobic respiration, nitric oxide anabolism, sulfur metabolism, host invasion, and protein histidyl modification to diphthamide. It localizes to the mitochondrial outer membrane, endoplasmic reticulum, and plasma membrane. Studies of related genes in other species link the family to nitrate transport and uptake, as well as molybdenum content.