GRX1 — Magnaporthe oryzae 70-15

Summary

MoGRX1 (MGG_05447) on chromosome 1 of Magnaporthe oryzae 70-15 encodes a glutaredoxin-C2 protein with glutathione disulfide oxidoreductase, glutathione peroxidase, and glutathione transferase activities (EC 1.11.1.9, 2.5.1.18). The gene is associated with appressorium formation, spore germination, the metabolic burst, removal of superoxide, and cellular response to oxidative stress. Its product localises to mitochondria, cytoplasm, cytosol, and nucleus. MoGRX1 is linked to decreased spore germination, abnormal cell wall morphology, decreased osmotic and ionic stress resistance, decreased acquired thermotolerance, decreased exponential-phase growth, increased lifespan, decreased apoptosis, abnormal autophagy, absent pexophagy, abnormal pseudohyphal growth, abnormal shmoo formation, increased pheromone sensitivity, decreased fermentative metabolism, decreased phosphorus utilisation, abnormal cell cycle progression in G1 phase, abnormal chromosome segregation, increased mitotic recombination, and abnormal budding index. Related genes in other species link the family to oxidative stress response.