UBA4 — Magnaporthe oryzae 70-15

Summary

MGG_05569 (UBA4) on chromosome 1 of Magnaporthe oryzae 70-15 encodes a MOCS3/Uba4 family protein with molybdopterin-synthase sulfurtransferase and adenylyltransferase activities, URM1 activating enzyme activity, and thiosulfate-cyanide sulfurtransferase activity. The gene is associated with tRNA thiolation, tRNA wobble uridine thiolation, protein urmylation, moco biosynthesis, regulation of pseudohyphal growth, cell budding, invasive growth in response to glucose limitation, innate immunity, translation elongation, secretion, and cellular response to oxidative stress. It is linked to numerous phenotypes including abnormal cell cycle progression, absent spore germination, sterility, increased ionic stress and alkaline pH resistance, delayed mitophagy and pexophagy, and abnormal autophagy, vacuolar distribution, and nuclear transport. The protein localises to the cytoplasm and cytosol. Studies of related genes in other species link the family to oxidative stress response.