SHD1 — Magnaporthe oryzae 70-15

Summary

MGG_05626 (MoSHD1) encodes a protein containing SH3 and SAM/pointed domains, with molecular functions including actin binding, ubiquitin binding, lipid binding, cargo adaptor activity, and transcription coregulator binding. It is associated with negative regulation of Arp2/3 complex-mediated actin nucleation, actin cortical patch assembly, endocytosis, autophagy, appressorium formation, invasive growth, hyphal growth, cell wall organization, and fungal-type cell wall biogenesis. The protein localizes to the cortical actin cytoskeleton, actin patches, endosome membranes, the SLAC complex, sites of polarized growth, and cell tips. Phenotypic associations include absent septum formation, abnormal spore germination, delayed vegetative growth, increased gamma ray resistance, and abnormal filamentous growth. Studies of related genes in other species link the family to reduced virulence.